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Oral Hypoglycemic Agents

Oral Hypoglycemic Agents

By Dr Motamed

Fellow of Endocrinology and Metabolism

Endocrine Research Center

 

Control of blood glucose is essential in diabetic patients with any possible method (Diet, Oral agents, or Insulin)

Otherwise, The complications of diabetes will appear

There currently are four therapeutic options for type 2 diabetes:

  • Increase insulin release with sulfonylureas or meglitinides
  •   Increase insulin responsiveness with a biguanide (metformin) or a thiazolidinedione
  •   Modify intestinal absorption of carbohydrate with an alpha-glucosidase inhibitor .
  • Administer exogenous insulin

 

Pharmacologic Therapy
for Type 2 Diabetes

  • Sulfonylureas (glyburide or glibenclamide)
  • Biguanides (metformin)
  • Alpha-glucosidase inhibitors (acarbose)
  • Benzoic acid analogues (repaglinide)
  • Thiazolidinediones ( pioglitazone)
  • Insulin (human insulin, insulin analogues)