METFORMIN

             METFORMIN

F.Hadaegh

Prevention of Metabolic Disorders Research Center

 Research Institute for Endocrine Sciences

                               2011-05-19

Metformin (dimethylbiguanide)

• is the only biguanide currently used in most countries .
• The history of biguanides stems from a guanidine - rich herb Galega officinalis (goat ’ s rue or French lilac) that was used as a traditional treatment for diabetes in Europe.

Mode of Action

• Metformin exerts a range of actions that counter insulin resistance and lower blood glucose:
• the drug also offers some protection against vascular complications independently of its antihyperglycemic effect