Application Quantum Physics on Bone Imaging 2019
Ali Ghasem-Zadeh
Depts of Endocrinology and Medicine, Austin Health The University of Melbourne Australia
Cortical porosity measurement, a challenging task:
HR-pQCT 100 µm spatial resolution in-vivo imaging
- Cortical pores ~40 to 100 µm, osteocyte lacunae (~10 to 30 µm), and canaliculi (~0.1 µm)
- Locating low density and small objects (pores, ~ 0 mgHA/cm3) in the relatively large and very high-density background (bone tissue >1000 mgHA/cm3)
- Cortical pores ~40 to 100 µm, osteocyte lacunae (~10 to 30 µm), and canaliculi (~0.1 µm)
- Locating low density and small objects (pores, ~ 0 mgHA/cm3) in the relatively large and very high-density background (bone tissue >1000 mgHA/cm3)
- Beam hardening effects associated with poly-energetic x-ray spectrum
- Larger point spread function in consequence of cone beam x-ray
Australian Synchrotron Radiation
- Monochromatic x-ray free of beam hardening
- Higher rate of beam flux from 6 to 120 keV
- Capability of scanning large objects with a greater scanning field of view
- Coherent and parallel beam
