Adrenal rest cells first described in 1940 are a group of cells trapped within the developing gonad during foetal development . Usually <5 mm in size, they are found in the testis and surrounding tissue in 7.5–15% of new born and in about 1.5% of adults
Congenital adrenal hyperplasia (CAH) is an autosomal recessive disorder caused by CYP 21(21-hydroxylase) deficiency. Testicular adrenal rest tumors (TARTs) are a complication of CAH, stimulated by the hypersecretion of adrenocorticotropic hormone (ACTH).
Ovarian adrenal rest tumors (OARTs) have been infrequently reported in affected women.