conferance lidel 26.10.1401

Low-Renin Hypertension

• Low-renin hypertension affects 30% of patients with hypertension.
•  The most common cause of low-renin hypertension is primary aldosteronism, which presents with suppressed renin but elevated aldosterone concentrations.
• Endocrinol Metab Clin N Am 48 (2019) 701–715
• Low-renin hypertension with low aldosterone represents a wide spectrum of disorders, which includes hereditary monogenic forms, secondary to either endogenous or exogenous factors, and essential forms.
• When evaluating a patient with low-renin hypertension, measurement of plasma aldosterone and potassium concentrations are followed by workup for differential diagnosis.
• Traditionally, the evaluation of the renin profiling was based on plasma renin activity (PRA), a radioimmuno assay (RIA) that measures the quantity of angiotensin I generated as a function of time.
•  More recently, the direct renin concentration (DRC), measured by chemiluminescence, and the liquid chromatography with mass spectrometry for quantification of PRA have emerged as alternative methods.
• Clinical Endocrinology. 2018;89:385–396.