Recommendations for screening primary hyperaldosteronism:
All patients with the combination of hypertension and hypokalemia, (spontaneous or diuretic-induced)
Young patients with hypertension,
Patients with early onset of cerebrovascular accident (<age 50),
Patients with a positive family history of early stroke in a first-degree relative,
Patients with hypertension and adrenal incidentalomas,
Those whose blood pressure is difficult to control (resistant hypertension),
Primary hyperaldosteronism is especially common among patients with resistant hypertension.
In evaluations by several different investigators, the prevalence of primary hyperaldosteronism has been consistently reported as about 20% among subjects with resistant hypertension.