A paraganglioma is a tumor derived from extra-adrenal chromaffin cells of the sympathetic paravertebral ganglia of thorax, abdomen, and pelvis.
About 80 to 85% of chromaffin-cell tumors are pheochromocytomas,
whereas 15 to20%are paragangliomas.
The prevalence of PPGL in patients with hypertension in general outpatient clinics varies between 0.2 and 0.6%.
Malignancy is defined as the presence of metastases in nonchromaffin tissue; the prevalence varies between 10 and 17%.