1397-1-20-discussion-presentation

GENETIC SCREENING — Genetic testing should be considered if a patient has one or more of the following:

• Paraganglioma
• Bilateral adrenal pheochromocytoma
• Unilateral adrenal pheochromocytoma and a family history of pheochromocytoma/paraganglioma
• Unilateral adrenal pheochromocytoma onset at a young age (eg, <45 years), or
• Other clinical findings suggestive of one of the syndromic disorders

An asymptomatic person at risk for disease on the basis of family history of pheochromocytoma/paraganglioma should have genetic testing only if an affected family member has a known mutation.