microadenomas are 4-5 fold more frequent than macroadenomas
The ratio between macro- and microprolactinomas is approximately 1:8 in women, whereas it is inverted in men (macroadenomas in 80% of cases)
predominance of PRL-secreting tumors is observed in women aged 25-44 years compared to men ( male to female ratio of 1:5 to 1:10) while this difference disappears after menopause.
peak age of occurrence in women occurs at approximately 30 years, while most men are diagnosed after age 50.