Conference DKD
Diabetic Nephropathy
Shahin Nosratzehi
Agenda
- Introduction
- Classical phenotype
- Mechanisms of DKD
- Immediate effects of hyperglycemia
- Late effects of hyperglycemia
- Non-protein uric phenotype
- Pathogenesis and risk factors
- NDKD in DM
- Screening
- Novel biomarkers for the early detection of Diabetic nephropathy
- Staging
- Surveillance
INTRODUCTION
- The prevalence of type 2 diabetes mellitus (T2DM) is steadily increasing, mostly due to a combination of obesity, urbanization, and ageing population.
- In parallel, the prevalence of its macrovascular and microvascular complications, such as diabetic nephropathy (DN), which occurs in 20 to 40% of type 2 diabetic patients, has risen.
- Despite efforts made to slow the progression of DN, this is still the most common cause of end-stage renal disease (ESRD) in developed countries.
Port J Nephrol Hypert 2017; 31(2): 122-131 123
- In the past, it was believed that DN only had one path of progression – from a normoalbuminuric stage, to microalbuminuria (UACR 30-300 mg/g), to end in overt proteinuria (UACR> 300 mg/g).
- However, in the last few years a growing body of evidence has shown an accelerated decrease in glomerular filtration rate (GFR) predominately seen in type 2 diabetic chronic kidney disease (CKD) patients with UACR< 300mg/g.
- This discovery has raised the possibility of their being two independent diabetic nephropathy phenotypes
Port J Nephrol Hypert 2017; 31(2): 122-131 123
