Outcome of Liver Transplant in Diabetic Patients in Shiraz Transplant Center

Outcome of Liver Transplant in Diabetic Patients in Shiraz Transplant Center

Rahmani P. Jeddi M. Moini M. Ranjbar Omrani Gh.

Presented by: Dr Marjan Jeddi

Endocrinology and Metabolism Research Center,

Shiraz University of Medical Sciences, Shiraz, IRAN

INTRODUCTION

• Liver transplantation is widely accepted as an effective therapeutic modality for acute and chronic liver failure
• Complications are common in the early and long term period and contribute to significant morbidity and mortality

PLTDM

• One of the most frequent complications after liver transplantation is the development new onset DM after transplant (NODAT)
• In addition to all the well-known complications of DM, NODAT is associated with reduced graft function, increased risk of transplant loss, increased incidence of infectious complications, and worsened patient survival

Outcome

• Several studies have examined the influence of preexisting DM  on  the  outcome  of  liver  transplantation, and the recent studies, with relative large samples and good design,  had  the  consensus  that  patients  with  DM  were associated with a marked higher post-transplant morbidity and mortality than those without DM
• But some other studies demonstrated that NODAT did not have any adverse consequence on patient prognosis after liver transplantation

The Aim

• The aim of this study is evaluation of post-transplant complication and comparing it in diabetic (pre existing DM or NODAT) and non-diabetic patients in Shiraz liver transplant center